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Contribution statement JAW, NJWA, JP and JJH contributed substantially to the concept and design of the study
Mice were treated with cotadutide, liraglutide, g1437 or liraglutide+g1437 at equimolar dosing (10 nmol/kg, SC, QD for 42 days) compared to vehicle
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Furthermore, icv leptin delivery improves expression of the metabolically relevant hypothalamic neuropeptides POMC, NPY, and AgRP in type 1 diabetes mice (Fujikawa et al., 2010)
Some effects occur within minutes, such as blood glucose and insulin concentrations, while others, such as effects on synaptic density, muscle mass, or bone density, may take months
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